Intrahepatic cholestasis in the newborn.

Hitherto little attention has been paid to cholestatic jaundice in the newborn which occurs in the absence of rhesus incompatibility. 4 such cases, among a consecutive series of 24 newborns with prolonged neonatal jaundice occurring in the Devon and Exeter clinical area since 1960, are here described in detail to demonstrate that their clinical and histological picture, and their prognosis, is quite distinct from that of other forms of prolonged obstructive neonatal jaundice. Attention is drawn to a possible relation between cholestatic jaundice in the newborn and absence of the intrahepatic bile-ducts in later infancy, and to the place of steroid therapy in the management of cholestatic jaundice. Case Reports